Feeling tired, gaining weight, or cold all the time? Those can be signs of an underactive thyroid. Synthroid is the brand name for levothyroxine, a synthetic thyroid hormone doctors give to replace what your thyroid can’t make. The goal is simple: get your thyroid blood tests (TSH and sometimes free T4) back into a range where you feel normal again.
Synthroid dosing isn’t one-size-fits-all. Your doctor will start with a dose based on your age, weight, other health problems, and blood tests. Many people need several small dose adjustments over weeks to months before things settle. That’s normal—don’t panic if your first prescription doesn’t make you feel perfect right away.
Watch how you feel and get labs checked. If your TSH is still high, you might need a dose increase. If it drops too low you could get symptoms of too much thyroid hormone—racing heart, shakiness, trouble sleeping. Both under- and over-treatment matter, especially for older adults and people with heart disease.
Take Synthroid on an empty stomach, ideally 30–60 minutes before breakfast or at least 3–4 hours after your last meal. Food, calcium, iron, and some antacids can block absorption and make the dose less effective. If you take calcium or iron supplements, separate them from Synthroid by at least four hours.
Always take it the same way every day. If you switch brands or move from brand-name to generic (or vice versa), tell your doctor—small differences can matter and your dose might need re-checking. Store pills in a cool, dry place away from sunlight. If you miss a dose, take it as soon as you remember that day; don’t double up the next day.
Levothyroxine is the standard treatment, but alternatives exist. Liothyronine (T3) is a faster-acting hormone sometimes added for people who still have symptoms despite normal TSH. Natural desiccated thyroid (brands like Armour) contains both T4 and T3 and works for some patients, though labs and responses can be less predictable. Combination T4/T3 prescriptions are another option, but they require careful monitoring.
Think about alternatives when you still feel unwell after months of stable labs, or if you have side effects that seem tied to one preparation. Always discuss changes with your clinician—switching treatments without testing can cause trouble.
Special situations: pregnant people need close monitoring because thyroid needs often rise. Older adults and those with heart disease need slower dose changes. If you buy meds online, choose trusted pharmacies and check that the product is genuine.
Want more? We have a detailed post on “7 Best Alternatives to Synthroid” that explains options, pros and cons, and when to talk to your doctor. If you follow these basics—consistent timing, watch labs, and stay in touch with your clinician—you’ll be in a good spot to manage thyroid replacement safely.
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