Sertraline is a common antidepressant in the SSRI class. Doctors prescribe it for major depression, panic disorder, social anxiety, PTSD, obsessive‑compulsive disorder, and premenstrual dysphoric disorder. It changes brain signals tied to mood and anxiety and can help most people feel more stable.
Typical starting doses are 25–50 mg once daily, often increased to 100 mg if needed. Some patients require lower or higher doses—doctors tailor treatment by symptoms and tolerance. Expect gradual improvement: sleep and appetite may change in the first week, while mood and anxiety often improve by 2–6 weeks. Keep taking it even if you don't feel better right away.
Common side effects include nausea, headache, insomnia, dry mouth, dizziness, and sexual problems such as reduced libido or delayed orgasm. These effects often ease after a few weeks. If side effects are severe or persistent, contact your prescriber—sometimes switching time of day or adjusting dose fixes the problem.
Avoid mixing sertraline with MAO inhibitors, certain migraine drugs (triptans), or other strong serotonergic medicines; combining them can cause serotonin syndrome, a serious condition. If you take blood thinners or NSAIDs, watch for increased bleeding risk. Don't stop sertraline suddenly—doing so can cause withdrawal symptoms like dizziness, irritability, or flu‑like feelings. Doctors usually reduce the dose slowly when stopping.
Young people up to 24 may have a higher risk of new or worsening suicidal thoughts when starting antidepressants. Families and caregivers should watch for mood changes, agitation, or self‑harm signs, especially in the first few months. Pregnant or breastfeeding people should discuss risks and benefits with their clinician—some women stay on sertraline because untreated depression also carries risks.
Take sertraline at the same time each day, with or without food. If you get stomach upset, take it with food. Skip alcohol—alcohol can make side effects worse and reduce benefit. Keep a simple log of symptoms and side effects to share at follow‑up visits; concrete notes help your prescriber adjust treatment faster.
Tell your doctor about all medications, supplements, and herbal remedies you use—St. John's wort, for example, can interact badly. Always use sertraline under medical supervision; a prescription is required. If cost or access is a concern, ask your pharmacist about generic sertraline options and patient assistance programs.
If you notice signs of serotonin syndrome (high fever, fast heartbeat, severe agitation, stiff muscles) or severe allergic reaction (hives, swelling, breathing trouble), seek emergency care. For routine questions or mild side effects, your pharmacist can often give quick advice or contact your prescriber for adjustments.
If you have trouble affording sertraline, ask about generic sertraline (sertraline HCl) or discount cards. Community clinics and some pharmacies offer low‑cost options. Never buy medicines from unknown foreign websites without a valid prescription. Check local patient assistance.
Sertraline helps many people regain functioning and reduce anxiety. With careful monitoring, clear communication with your healthcare team, and patience during the first weeks, most people get meaningful benefit while minimizing risks.
Finding the right medication for mental health can be tricky, especially when Trazodone might not suit everyone's needs. This guide breaks down six potential alternatives to Trazodone, offering diverse options for those seeking help with depression, anxiety, or insomnia. Each alternative's unique qualities, benefits, and drawbacks are explored, helping readers make informed decisions alongside their healthcare providers.
