Efavirenz is an antiretroviral medicine used to treat HIV-1. It belongs to the NNRTI class (non-nucleoside reverse transcriptase inhibitors), which blocks the virus from copying its genetic material. Doctors commonly use efavirenz as part of a multi-drug regimen to lower viral load and protect the immune system.
The usual adult dose is 600 mg once daily, taken at bedtime. Taking it at night and on an empty stomach often reduces dizziness, vivid dreams, and other central nervous system effects. Always follow your prescriber's instructions—some modern regimens use lower doses or substitute other drugs depending on resistance tests and side effects.
If you miss a dose and it's more than a few hours late, skip it and take the next dose at the usual time. Do not double up. Stopping efavirenz suddenly can allow the virus to rebound and may cause resistance. Talk to your clinic before changing or stopping treatment.
Common side effects show up early: dizziness, blurred vision, vivid dreams, trouble sleeping, and mood changes. Most people see these ease after a few weeks. Still, if you have new or worsening depression, suicidal thoughts, or severe mood swings, contact your healthcare provider right away.
Efavirenz can cause skin rashes. Minor rashes are common, but severe allergic reactions or widespread rashes need urgent care. The drug is also processed by the liver, so your provider will check liver tests before and during treatment—especially if you have hepatitis B or C, or drink alcohol regularly.
Pregnancy and planning a pregnancy deserve special attention. Studies and safety reports raised concerns about early pregnancy exposure. Women who are pregnant or trying to conceive should discuss alternatives with their clinician and consider effective contraception while on efavirenz.
Efavirenz interacts with many medicines. It affects CYP450 enzymes in the liver, so levels of other drugs can rise or fall. Notable interactions: methadone (may lower levels), hormonal birth control (can be affected), rifampin, some benzodiazepines, and herbal supplements like St. John's Wort (can reduce efavirenz levels). Always give your provider a full list of medicines, vitamins, and herbs.
Monitoring is simple and helps avoid trouble. Expect baseline labs for viral load, CD4 count, liver enzymes, and a pregnancy test if relevant. Your clinic will repeat tests after starting therapy and whenever side effects appear.
Buying efavirenz online? Only use licensed pharmacies that require a prescription and offer pharmacist contact. Beware of extremely low prices, no-prescription sellers, or sites without clear company details. If you’re unsure, ask your healthcare team for a recommended pharmacy.
Efavirenz is an effective part of HIV care for many people, but it has specific risks and interactions. Talk openly with your provider about mental health, pregnancy plans, other meds, and any side effects—you’ll get the safest and most effective plan that way.
Efavirenz is commonly used in pediatric HIV treatment, but understanding its safety and efficacy can help parents make informed decisions. This article delves into its benefits, potential side effects, and tips for safe administration in children. With insights backed by recent research, it serves as a practical guide for caregivers ensuring effective treatment for young patients.
